Publications

Dr Lynch has published widely in the fields of skin cancer, skin biology, epigenetics and artificial intelligence. His research spans spatial and single-cell genomics of healthy and diseased skin, clinical dermatology, and the application of machine learning to dermatological diagnosis.

46 peer-reviewed publications

1. Du-Harpur X, Ganier C, Mazin P, Cheshire C, Gabriel J, Rashidghamat E, Luscombe NM, Lynch MD, Watt FM. Pathogenic Keratinocyte States and Fibroblast Niches Define the Tissue Microenvironment in Severe Hidradenitis Suppurativa. Journal of Investigative Dermatology, 2025. In press
2. Yu GT,...Lynch MD...,Wyles S. SenSkinTM: A Human Skin-Specific Cellular Senescence Gene Set. Geroscience, 2025. In press
3. Lynch MD. Beyond the algorithm: Ethical Challenges in AI-Driven Skin Cancer Diagnosis. British Journal of Dermatology, 2024. DOI
4. Lynch MD, Wyles S. Regenerative Medicine: On the Vanguard of Dermatology.. Dermatologic Surgery, 2024. Pubmed
5. Wyles S, Lynch MD. Introduction to special issue on Regenerative Medicine. Dermatologic Surgery, 2024. Pubmed
6. Yu GT, Ganier C, Allison DB, Tchkonia T, Khosla S, Kirkland JL, Lynch MD, Wyles S. Mapping epidermal and dermal cellular senescence in human skin aging. Aging Cell, 2024. Pubmed
7. Ziebart R, Antezana L, Crum O, Lynch MD, Wyles S. Laser and Energy Treatments for Acne Scarring: A Review. Journal of Drugs and Dermatology, 2024. In Press
8. Sood A, Mansoor N, Memmi C, Lynch MD, Lynch JO. Generative Pretrained Transformer-4, an artificial intelligence text predictive model, has a high capability for passing novel written radiology exam questions. International Journal of Computer Assisted Radiology and Surgery, 2024. Pubmed
9. Ganier C, Mazin P, Herrera-Oropeza G, Du-Harpur X, Blakeley M, Gabriel J, Predeus AV, Cakir B, Prete M, Harun N, Darrigrand JF, Haiser A, Wyles S, Shaw T, Teichmann SA, Haniffa M, Watt FM, Lynch MD. Multiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma. Proc Natl Acad Sci, 2024. Pubmed
10. Hughes S, Srenathan H, Lynch MD (Joint senior author), Leeman H. Multi-center experience from tertiary skin cancer units on the role of Sentinel Lymph Node Biopsy in patients with pT1b melanoma. Clin Exp Dermatol, 2023. Pubmed
11. Shetty M, Ettlinger M, Lynch MD. GPT-4, an artificial intelligence large language model, exhibits high levels of accuracy on dermatology specialty certificate exam questions. medrxiv, 2023. Link
12. Banila C, Green D, Katsanos D, Viana J, Osmaston A, Vasquez AM, Lynch MD, Kaveh S. A non-invasive method for whole-genome skin methylome profiling. British Journal of Dermatology, 2023. Pubmed
13. Mahil S, Choy SP, Kim BJ, Paolino A, Tan WR, Lim S, Seo J, Tan SP, Francis L, Tsakok T, Simpson M, Barker J, Lynch MD, Corbett M, and Smith C. Systematic review of deep learning image analyses for the diagnosis and monitoring of skin disease. npj Digital Medicine, 2023. Pubmed
14. Ganier C, Rognoni E, Goss G, Lynch MD, Watt FM. Fibroblast heterogeneity in healthy and wounded skin. Cold Spring Harbour Perspectives in Biology, 2022. Pubmed
15. Kravvas G, Asif M, Watchorn R, Castiglione F, Haider A, Freeman A, Hadway P, Hussain Alnajjar, Lynch MD, Bunker C. Male genital lichen sclerosus, micro incontinence and occlusion: mapping the disease across the prepuce. Clinical and Experimental Dermatology, 2023. Pubmed
16. Cunningham L, Ganier C, Ferguson F, White IR, Watt FM, McFadden J, Lynch MD. Gradient boosting approaches can outperform logistic regression for risk prediction in cutaneous allergy. Contact Dermatitis, 2021. Pubmed
17. Ganier C, Harun N, Peplow I, Du-Harper X, Arthurs C, Watt FM, Lynch MD. ACE2 expression is detectable in keratinocytes, cutaneous appendages and blood vessels by multiplex RNA in situ hybridization. Adv Skin Wound Care, 2021. Pubmed
18. Lakhan M, Lynch MD. Skin Pigmentation. Medicine, 2021. Link
19. Reynolds G, Vegh P, Fletcher J,... Lynch M,...Teichmann S, Watt F, Haniffa M. Developmental cell programs are co-opted in inflammatory skin disease. Science, 2021. Pubmed
20. Wan B, Ganier C, Du-Harpur X, Harun N, Watt F, Patalay R, Lynch MD. Applications and future directions for Optical Coherence Tomography in Dermatology. British Journal of Dermatology, 2021. Pubmed
21. Du-Harpur X, Arthurs C, Ganier C, Woolf RT, Laftah Z, Lakhan MK, Salam A, Wan B, Watt FM, Luscombe NM, Lynch MD. Clinically-relevant vulnerabilities of deep machine learning systems for skin cancer diagnosis. Journal of Investigative Dermatology, 2020. Pubmed
22. Du-Harpur X, Luscombe N, Watt FM, Lynch MD. What is AI? Applications of artificial intelligence to dermatology. British Journal of Dermatology, 2020. Pubmed
23. Teo Y, McFadden J, White I, Lynch MD and Banerjee P. Allergic Contact Dermatitis in Atopic Individuals: Results of a 30-year Retrospective Study. Contact Dermatitis, 2020. Pubmed
24. van de Lagemaat LN, Flenley M, Lynch MD, Garrick D, Tomlinson SR, Kranc KR, Vernimmen D. CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands. Epigenetics Chromatin, 2018. Pubmed
25. Philippeos C, Telerman S, Oules B, Pisco A, Shaw T, Elgueta R, Lombardi G, Driskell R, Soldin M, Lynch MD and Watt F. Spatial and single-cell transcriptional profiling identifies functionally distinct human dermal fibroblast subpopulations. Journal of Investigative Dermatology, 2018. Pubmed
26. Lynch MD, Watt FM. Fibroblast heterogeneity: Implications for human disease. Journal of Clinical Investigation, 2018. Pubmed
27. Lynch MD, Lynch CNS, Craythorne E, Liakath-Ali K, Mallipeddi R, Barker JN and Watt FM. Spatial constraints govern competition of mutant clones in human epidermis. Nature Communications, 2017. Pubmed
28. Lynch MD, McFadden JP, White JM, Banerjee P, White IR. Age-specific profiling of cutaneous allergy at high temporal resolution suggests age-related alterations in regulatory immune function. Journal of Allergy and Clinical Immunology, 2017. Pubmed
29. Lynch MD, White JM, McFadden JP, Wang Y, White IR, Banerjee P. A dynamic landscape of allergen associations in delayed-type cutaneous hypersensitivity. British Journal of Dermatology, 2017. Pubmed
30. Jeziorska DM, Murray RJS, De Gobbi M, Gaentzsch R, Garrick D, Ayyub H, Chen T, Li E, Telenius J, Lynch MD, Graham B, Smith AJH, Lund JN, Hughes JR, Higgs DR, Tufarelli C. DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease. Proc Natl Acad Sci, 2017. Pubmed
31. Alwan W, Lynch M, McFadden J, White IR, Banerjee P. Patch testing in psoriasis patients: results of a 30-year retrospective cohort study. British Journal of Dermatology, 2017. Pubmed
32. Lynch MD, Ali F, Mallipeddi R. A pedunculated nasal nodule. British Medical Journal, 2017. Pubmed
33. Lynch MD, Bashir S. Applications of Platelet-Rich-Plasma in Dermatology: A Critical Appraisal of the Literature. J Dermatol Treatment, 2016. Pubmed
34. Lynch MD, Sears A, Cookson H, Lew T, Laftah Z, Orrin L, Zuckerman M, Creamer D, Higgins E. Disseminated Coxsackievirus A6 affecting children with atopic dermatitis. Clin Exp Dermatol, 2014. Pubmed
35. Lynch MD, Cliffe J, Morris-Jones R. Authors' reply to Cockayne and colleagues. BMJ, 2014.
36. Lynch MD, Cliffe J, Morris-Jones R. Management of cutaneous viral warts. BMJ, 2014. Pubmed
37. Hughes JR, Roberts N, McGowan S, Hay D, Giannoulatou E, Lynch MD, De Gobbi M, Taylor S, Gibbons R, Higgs DR. Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment. Nat Genet, 2014. Pubmed
38. Lynch MD, Smith AJ, de Gobbi M, Flenley M, Hughes JR, Vernimmen D, Ayyub H, Sharpe JA, Sloane-Stanley JA, Sutherland L, Meek S, Burdon T, Gibbons RJ, Garrick D, Higgs DR. An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. EMBO Journal, 2011. Pubmed
39. Vernimmen D, Lynch MD, de Gobbi M, Garrick D, Sharpe JA, Sloane-Stanley JA, Smith AJ, Higgs DR. Polycomb Eviction as a New Distant Enhancer Function. Genes & Dev, 2011. Pubmed
40. Kowalczyk MS, Hughes JR, Lynch MD, Garrick D, Sharpe JA, Sloane-Stanley JA, McGowan SJ, De Gobbi M, Hosseini M, Vernimmen D, Brown JM, Gray NE, Collavin L, Gibbons RJ, Flint J, Taylor S, Buckle VJ, Milne TA, Wood WG, Higgs DR. Intragenic enhancers act as alternative promoters. Mol Cell, 2012. Pubmed
41. De Gobbi M, Garrick D, Lynch MD, Vernimmen D, Hughes JR, Goardon N, Luc S, Lower KM, Sloane-Stanley JA, Pina C, Soneji S, Renella R, Enver T, Taylor S, Jacobsen SEW, Vyas P, Gibbons RJ, Higgs DR. Generation of Bivalent Chromatin Domains During Cell Fate Decisions. Epigenetics and Chromatin, 2011. Pubmed
42. Garrick D, De Gobbi M, Lynch MD, Higgs DR. Switching genes on and off in haemopoiesis. Biochem Soc Trans, 2008. Pubmed
43. Lynch MD, Cariati M, Purushotham AD. Breast cancer, stem cells and prospects for therapy. Breast Cancer Res, 2006. Pubmed
44. Lynch MD, Jones AE, Marker A, Grant JW, Purushotham AD. Malignant eccrine poroma in breast cancer-related lymphoedema. Ann R Coll Surg Engl, 2004. Pubmed
45. Lynch MD. How does cellular senescence prevent cancer?. DNA Cell Biol, 2006. Pubmed
46. Lynch MD. The role of cellular senescence may be to prevent proliferation of neighboring cells within stem cell niches. Ann N Y Acad Sci, 2004. Pubmed