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DR MAGNUS LYNCH
Publications
Lynch MD. Beyond the algorithm: Ethical Challenges in AI-Driven Skin Cancer Diagnosis. British Journal of Dermatology, 2024.
DOI: 10.1093/bjd/ljae490
Lynch MD, Wyles S. Regenerative Medicine: On the Vanguard of Dermatology.. Dermatologic Surgery, 2024.
Pubmed ID: 39480033
Wyles S, Lynch MD. Introduction to special issue on Regenerative Medicine. Dermatologic Surgery, 2024.
Pubmed ID: 39480032
Yu GT, Ganier C, , Allison DB, Tchkonia T, Khosla S, Kirkland JL, Lynch MD, Wyles S. Mapping epidermal and dermal cellular senescence in human skin aging. Aging Cell, 2024.
Pubmed ID: 39370688
Ziebart R, Antezana L, Crum O, Lynch MD, Wyles S. Laser and Energy Treatments for Acne Scarring: A Review. Journal of Drugs and Dermatology, 2024.
In Press
Sood A, Mansoor N, Memmi C, Lynch MD, Lynch JO. Generative Pretrained Transformer-4, an artificial intelligence text predictive model, has a high capability for passing novel written radiology exam questions. International Journal of Computer Assisted Radiology and Surgery, 2024.
Pubmed ID: 38381363
Ganier C, Mazin P, Herrera-Oropeza G, Du-Harpur X, Blakeley M, Gabriel J, Predeus AV, Cakir B, Prete M, Harun N, Darrigrand JF, Haiser A, Wyles S, Shaw T, Teichmann SA, Haniffa M, Watt FM, Lynch MD. Multiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma. Proc Natl Acad Sci, 2024.
Pubmed ID: 38165934
Hughes S, Srenathan H, Lynch MD (Joint senior author), Leeman H. Multi-center experience from tertiary skin cancer units on the role of Sentinel Lymph Node Biopsy in patients with pT1b melanoma. Clin Exp Dermatol, 2023.
Pubmed ID: 38112606
Shetty M, Ettlinger M, Lynch MD. GPT-4, an artificial intelligence large language model, exhibits high levels of accuracy on dermatology specialty certificate exam questions. medrxiv, 2023.
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Banila C, Green D, Katsanos D, Viana J, Osmaston A, Vasquez AM, Lynch MD, Kaveh S. A non-invasive method for whole-genome skin methylome profiling. British Journal of Dermatology, 2023.
Pubmed ID: 37658851
Mahil S, Choy SP, Kim BJ, Paolino A, Tan WR, Lim S, Seo J, Tan SP, Francis L, Tsakok T, Simpson M, Barker J, Lynch MD, Corbett M, and Smith C. Systematic review of deep learning image analyses for the diagnosis and monitoring of skin disease. npj Digital Medicine, 2023.
Pubmed ID: 37758829
Ganier C, Rognoni E, Goss G, Lynch MD, Watt FM. Fibroblast heterogeneity in healthy and wounded skin. Cold Spring Harbour Perspectives in Biology, 2022.
Pubmed ID: 35667795
Kravvas G, Asif M, Watchorn R, Castiglione F, Haider A, Freeman A, Hadway P, Hussain Alnajjar, Lynch MD, Bunker C. Male genital lichen sclerosus, micro incontinence and occlusion: mapping the disease across the prepuce. Clinical and Experimental Dermatology, 2023.
Pubmed ID: 35150005
Cunningham L, Ganier C, Ferguson F, White IR, Watt FM, McFadden J, Lynch MD. Gradient boosting approaches can outperform logistic regression for risk prediction in cutaneous allergy. Contact Dermatitis, 2021.
Pubmed ID: 34812539
Ganier C, Harun N, Peplow I, Du-Harper X, Arthurs C, Watt FM, Lynch MD. ACE2 expression is detectable in keratinocytes, cutaneous appendages and blood vessels by multiplex RNA in situ hybridization. Adv Skin Wound Care, 2021.
Pubmed ID: 35085122
Lakhan M, Lynch MD. Skin Pigmentation. Medicine, 2021.
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Reynolds G, Vegh P, Fletcher J,… Lynch M,…Teichmann S, Watt F, Haniffa M. Developmental cell programs are co-opted in inflammatory skin disease. Science, 2021.
Pubmed ID: 33479125
Wan B, Ganier C, Du-Harpur X, Harun N, Watt F, Patalay R, Lynch MD. Applications and future directions for Optical Coherence Tomography in Dermatology. British Journal of Dermatology, 2021.
Pubmed ID: 32974943
Du-Harpur X, Arthurs C, Ganier C, Woolf RT, Laftah Z, Lakhan MK, Salam A, Wan B, Watt FM, Luscombe NM, Lynch MD. Clinically-relevant vulnerabilities of deep machine learning systems for skin cancer diagnosis. Journal of Investigative Dermatology, 2020.
Pubmed ID: 32931808
Du-Harpur X, Luscombe N, Watt FM, Lynch MD. What is AI? Applications of artificial intelligence to dermatology. British Journal of Dermatology, 2020.
Pubmed ID: 31960407
Teo Y, McFadden J, White I, Lynch MD1. and Banerjee P1.. Allergic Contact Dermatitis in Atopic Individuals: Results of a 30-year Retrospective Study. Contact Dermatitis, 2020.
Pubmed ID: 31347185
van de Lagemaat LN, Flenley M, Lynch MD, Garrick D, Tomlinson SR, Kranc KR, Vernimmen D. CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands. Epigenetics Chromatin, 2018.
Pubmed ID: 30292235
Philippeos C, Telerman S, Oulès B, Pisco A, Shaw T, Elgueta R, Lombardi G, Driskell R, Soldin M, Lynch MD1. and Watt F. Spatial and single-cell transcriptional profiling identifies functionally distinct human dermal fibroblast subpopulations. Journal of Investigative Dermatology, 2018.
Pubmed ID: 29391249
Lynch MD, Watt FM. Fibroblast heterogeneity: Implications for human disease. Journal of Clinical Investigation, 2018.
Pubmed ID: 29293096
Lynch MD, Lynch CNS, Craythorne E, Liakath-Ali K, Mallipeddi R, Barker JN and Watt FM. Spatial constraints govern competition of mutant clones in human epidermis. Nature Communications, 2017.
Pubmed ID: 29066762
Lynch MD, McFadden JP, White JM, Banerjee P, White IR. Age-specific profiling of cutaneous allergy at high temporal resolution suggests age-related alterations in regulatory immune function. Journal of Allergy and Clinical Immunology, 2017.
Pubmed ID: 28606588
Lynch MD, White JM, McFadden JP, Wang Y, White IR, Banerjee P. A dynamic landscape of allergen associations in delayed-type cutaneous hypersensitivity. British Journal of Dermatology, 2017.
Pubmed ID: 27285898
Jeziorska DM, Murray RJS, De Gobbi M, Gaentzsch R, Garrick D, Ayyub H, Chen T, Li E, Telenius J, Lynch MD, Graham B, Smith AJH, Lund JN, Hughes JR, Higgs DR, Tufarelli C. DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease. Proc Natl Acad Sci, 2017.
Pubmed ID: 28827334
Alwan W, Lynch M, McFadden J, White IR, Banerjee P. Patch testing in psoriasis patients: results of a 30-year retrospective cohort study. British Journal of Dermatology, 2017.
Pubmed ID: 28617935
Lynch MD, Ali F, Mallipeddi R. A pedunculated nasal nodule. British Medical Journal, 2017.
Pubmed ID: 28254755
Lynch MD, Bashir S. Applications of Platelet-Rich-Plasma in Dermatology: A Critical Appraisal of the Literature. J Dermatol Treatment, 2016.
Pubmed ID: 26466811
Lynch MD, Sears A, Cookson H, Lew T, Laftah Z, Orrin L, Zuckerman M, Creamer D, Higgins E. Disseminated Coxsackievirus A6 affecting children with atopic dermatitis. Clin Exp Dermatol, 2014.
Pubmed ID: 25677678
Lynch MD, Cliffe J, Morris-Jones R. Authors' reply to Cockayne and colleagues. BMJ, 2014.
Lynch MD, Cliffe J, Morris-Jones R. Management of cutaneous viral warts. BMJ, 2014.
Pubmed ID: 24865780
Hughes JR, Roberts N, McGowan S, Hay D, Giannoulatou E, Lynch MD, De Gobbi M, Taylor S, Gibbons R, Higgs DR. Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment. Nat Genet, 2014.
Pubmed ID: 24413732
Vernimmen D, Lynch MD, de Gobbi M, Garrick D, Sharpe JA, Sloane-Stanley JA, Smith AJ, Higgs DR. Polycomb Eviction as a New Distant Enhancer Function. Genes & Dev, 2011.
Pubmed ID: 21828268
Kowalczyk MS, Hughes JR, Lynch MD1., Garrick D1., Sharpe JA, Sloane-Stanley JA, McGowan SJ, De Gobbi M, Hosseini M, Vernimmen D, Brown JM, Gray NE, Collavin L, Gibbons RJ, Flint J, Taylor S, Buckle VJ, Milne TA, Wood WG, Higgs DR. Intragenic enhancers act as alternative promoters. Mol Cell, 2012.
Pubmed ID: 22264824
De Gobbi M, Garrick D, Lynch MD, Vernimmen D, Hughes JR, Goardon N, Luc S, Lower KM, Sloane-Stanley JA, Pina C, Soneji S, Renella R, Enver T, Taylor S, Jacobsen SEW, Vyas P, Gibbons RJ, Higgs DR. Generation of Bivalent Chromatin Domains During Cell Fate Decisions. Epigenetics and Chromatin, 2011.
Pubmed ID: 21645363
Garrick D, De Gobbi M, Lynch MD, Higgs DR. Switching genes on and off in haemopoiesis. Biochem Soc Trans, 2008.
Pubmed ID: 18631127
Lynch MD, Cariati M, Purushotham AD. Breast cancer, stem cells and prospects for therapy. Breast Cancer Res, 2006.
Pubmed ID: 16834766
Lynch MD, Jones AE, Marker A, Grant JW, Purushotham AD. Malignant eccrine poroma in breast cancer-related lymphoedema. Ann R Coll Surg Engl, 2004.
Pubmed ID: 16749962
Lynch MD. How does cellular senescence prevent cancer?. DNA Cell Biol, 2006.
Pubmed ID: 16460230
Lynch MD. The role of cellular senescence may be to prevent proliferation of neighboring cells within stem cell niches. Ann N Y Acad Sci, 2004.
Pubmed ID: 15247012