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DR MAGNUS LYNCH
Publications
  1. Ziebart R, Antezana L, Crum O, Lynch MD, Wyles S. Laser and Energy Treatments for Acne Scarring: A Review. Journal of Drugs and Dermatology, In Press.
  2. Sood A, Mansoor N, Memmi C, Lynch MD, Lynch JO. Generative Pretrained Transformer-4, an artificial intelligence text predictive model, has a high capability for passing novel written radiology exam questions. International Journal of Computer Assisted Radiology and Surgery. 2024. In Press.
  3. Ganier C, Mazin P, Herrera-Oropeza G, Du-Harpur X, Blakeley M, Gabriel J, Predeus AV, Cakir B, Prete M, Harun N, Darrigrand JF, Haiser A, Wyles S, Shaw T, Teichmann SA, Haniffa M, Watt FM, Lynch MD. Multiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma. Proc Natl Acad Sci, 2024. In Press.
  4. Hughes S, Srenathan H, Lynch MD (Joint senior author), Leeman H. Multi-center experience from tertiary skin cancer units on the role of Sentinel Lymph Node Biopsy in patients with pT1b melanoma. Clin Exp Dermatol, 2023. In Press.
  5. Shetty M, Ettlinger M, Lynch MD. GPT-4, an artificial intelligence large language model, exhibits high levels of accuracy on dermatology specialty certificate exam questions. medrxiv
  6. Banila C, Green D, Katsanos D, Viana J, Osmaston A, Vasquez AM, Lynch MD, Kaveh S. A non-invasive method for whole-genome skin methylome profiling. British Journal of Dermatology. 2023. In press.
  7. Mahil S, Choy SP, Kim BJ, Paolino A, Tan WR, Lim S, Seo J, Tan SP, Francis L, Tsakok T, Simpson M, Barker J, Lynch MD, Corbett M, and Smith C. Systematic review of deep learning image analyses for the diagnosis and monitoring of skin disease. npj Digital Medicine. In press.
  8. Ganier C, Rognoni E, Goss G, Lynch MD, Watt FM. Fibroblast heterogeneity in healthy and wounded skin. Cold Spring Harbour Perspectives in Biology, In press.
  9. Kravvas G, Asif M, Watchorn R, Castiglione F, Haider A, Freeman A, Hadway P, Hussain Alnajjar, Lynch MD, Bunker C. Male genital lichen sclerosus, micro incontinence and occlusion: mapping the disease across the prepuce. Clinical and Experimental Dermatology. In press.
  10. Cunningham L, Ganier C, Ferguson F, White IR, Watt FM, McFadden J, Lynch MD. Gradient boosting approaches can outperform logistic regression for risk prediction in cutaneous allergy. Contact Dermatitis, 2021. In Press.
  11. Ganier C, Harun N, Peplow I, Du-Harper X, Arthurs C, Watt FM, Lynch MD. ACE2 expression is detectable in keratinocytes, cutaneous appendages and blood vessels by multiplex RNA in situ hybridization. Adv Skin Wound Care, 2021. In Press.
  12. Lakhan M, Lynch MD. Skin Pigmentation. Medicine 2021 (Review) DOI:https://doi.org/10.1016/j.mpmed.2021.04.010
  13. Reynolds G, Vegh P, Fletcher J,… Lynch M,…Teichmann S, Watt F, Haniffa M. Developmental cell programs are co-opted in inflammatory skin disease. Science 2021 371(6527):eaba6500
  14. Wan B1., Ganier C1., Du-Harpur X, Harun N, Watt F, Patalay R, Lynch MD. Applications and future directions for Optical Coherence Tomography in Dermatology (review). British Journal of Dermatology. In Press
  15. Du-Harpur X, Arthurs C, Ganier C, Woolf RT, Laftah Z,Lakhan, MK, Salam A, Wan B, Watt FM, Luscombe NM, Lynch MD. Clinically-relevant vulnerabilities of deep machine learning systems for skin cancer diagnosis. Journal of Investigative Dermatology 2020 S0022.
  16. Du-Harpur X, Luscombe N, Watt FM, Lynch MD. What is AI? Applications of artificial intelligence to dermatology. British Journal of Dermatology 2020 183:423.
  17. Teo Y, McFadden J, White I, Lynch MD1. and Banerjee P1.. Allergic Contact Dermatitis in Atopic Individuals: Results of a 30-year Retrospective Study. Contact Dermatitis 2020. In Press 1.equal contribution
  18. van de Lagemaat LN, Flenley M, Lynch MD, Garrick D, Tomlinson SR, Kranc KR, Vernimmen D. CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands. Epigenetics Chromatin. 2018 Oct 6;11(1):59.
  19. Philippeos C, Telerman S, Oulès B, Pisco A, Shaw T, Elgueta R, Lombardi G, Driskell R, Soldin M, Lynch MD1. and Watt F, Spatial and single-cell transcriptional profiling identifies functionally distinct human dermal fibroblast subpopulations. 2018 138:811. 1.joint senior author
  20. Lynch MD, Watt FM Fibroblast heterogeneity: Implications for human disease (review). Journal of Clinical Investigation 2018. 128:26-35.
  21. Lynch MD, Lynch CNS, Craythorne E, Liakath-Ali K, Mallipeddi R, Barker JN and Watt FM. Spatial constraints govern competition of mutant clones in human epidermis. Nature Communications 2017. 8:1119.
  22. Lynch MD, McFadden JP, White JM, Banerjee P, White IR. Age-specific profiling of cutaneous allergy at high temporal resolution suggests age-related alterations in regulatory immune function. Journal of Allergy and Clinical Immunology 2017. 140:1451-1453
  23. Lynch MD, White JM, McFadden JP, Wang Y, White IR, Banerjee P. A dynamic landscape of allergen associations in delayed-type cutaneous hypersensitivity. British Journal of Dermatology 2017 176:184.
  24. Jeziorska DM, Murray RJS, De Gobbi M, Gaentzsch R, Garrick D, Ayyub H, Chen T, Li E, Telenius J, Lynch MD, Graham B, Smith AJH, Lund JN, Hughes JR, Higgs DR, Tufarelli C. DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease. Proc Natl Acad Sci. 2017. 114:E7526-E7535.
  25. Alwan W, Lynch M, McFadden J, White IR, Banerjee P. Patch testing in psoriasis patients: results of a 30-year retrospective cohort study. British Journal of Dermatology 2017 in press
  26. Lynch MD, Ali F, Mallipeddi R. A pedunculated nasal nodule. British Medical Journal 2017 356:j763.
  27. Lynch MD, Bashir S. Applications of Platelet-Rich-Plasma in Dermatology: A Critical Appraisal of the Literature. J Dermatol Treatment 2016. 27:285
  28. Lynch MD, Sears A, Cookson H, Lew T, Laftah Z, Orrin L, Zuckerman M, Creamer D, Higgins E. Disseminated Coxsackievirus A6 affecting children with atopic dermatitis. Clin Exp Dermatol. 2014. 40:525
  29. Lynch MD, Cliffe J, Morris-Jones R. Authors' reply to Cockayne and colleagues. BMJ 2014 348:g4092.
  30. Lynch MD, Cliffe J, Morris-Jones R. Management of cutaneous viral warts. BMJ. 2014 348:g3339. Review.
  31. Hughes JR, Roberts N, McGowan S, Hay D, Giannoulatou E, Lynch MD, De Gobbi M, Taylor S, Gibbons R, Higgs DR. Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment. Nat Genet. 2014 46:205-12.
  32. Lynch MD, Smith AJ, de Gobbi M, Flenley M, Hughes JR, Vernimmen D, Ayyub H, Sharpe JA, Sloane-Stanley JA, Sutherland L, Meek S, Burdon T, Gibbons RJ, Garrick D, Higgs DR. An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. EMBO Journal Nov 2011
  33. Vernimmen D. Lynch MD, de Gobbi M, Garrick D, Sharpe JA, Sloane-Stanley JA, Smith AJ, Higgs DR. Polycomb Eviction as a New Distant Enhancer Function. Genes & Dev, 2011 25:1583-8.
  34. Kowalczyk MS, Hughes JR, Lynch MD1., Garrick D1., Sharpe JA, Sloane-Stanley JA, McGowan SJ, De Gobbi M, Hosseini M, Vernimmen D, Brown JM, Gray NE, Collavin L, Gibbons RJ, Flint J, Taylor S, Buckle VJ, Milne TA, Wood WG, Higgs DR. Intragenic enhancers act as alternative promoters. Mol Cell 2012 45:447-458 1.equal contribution
  35. De Gobbi M, Garrick D, Lynch MD, Vernimmen D, Hughes JR, Goardon N, Luc S, Lower KM, Sloane-Stanley JA, Pina C, Soneji S, Renella R, Enver T, Taylor S, Jacobsen SEW, Vyas P, Gibbons RJ, Higgs DR. Generation of Bivalent Chromatin Domains During Cell Fate Decisions. Epigenetics and Chromatin, 2011 4:9
  36. Garrick D, De Gobbi M, Lynch MD, Higgs DR. Switching genes on and off in haemopoiesis. Biochem Soc Trans. 2008 36:613-8. (Review)
  37. Lynch MD, Cariati M, Purushotham AD. Breast cancer, stem cells and prospects for therapy. Breast Cancer Res. 2006 8:211. (Review)
  38. Lynch MD, Jones AE, Marker A, Grant JW, Purushotham AD. Malignant eccrine poroma in breast cancer-related lymphoedema. Ann R Coll Surg Engl. 2004 86:W32-5.
  39. Lynch MD. How does cellular senescence prevent cancer? DNA Cell Biol. 2006 25:69-78. Review
  40. Lynch MD. The role of cellular senescence may be to prevent proliferation of neighboring cells within stem cell niches. Ann N Y Acad Sci. 2004. 1019:191-4.
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