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Acrokeratosis verruciformis

Multiple, flat-topped papules on the dorsum of hands and feet, which is a genetic disorder, not an infection.

Actinic keratosis

A pre-malignant, rough, scaly patch on sun-exposed skin, which lacks the verrucous surface and thrombosed capillaries of a wart.

Amelanocytic melanoma

A pink, nodular lesion that can be verrucous, but is distinguished by rapid growth or ulceration and must be excluded by biopsy.

Arsenical keratosis

Multiple, hard, yellowish, punctate keratoses on the palms and soles, arising from chronic arsenic exposure.

Basal cell carcinoma

Can be papular but is distinguished by its pearly, translucent quality and surface telangiectasias.

Corn

A painful, focal hyperkeratosis over a bony prominence, which has a hard central core and does not disrupt skin lines like a wart.

Dermatofibroma

A firm, dermal nodule that dimples with lateral pressure, a feature not seen in warts.

Hypertrophic lichen planus

Thick, extremely pruritic, violaceous plaques, most often on the shins, a distinct color and symptomatology.

Keratoacanthoma

A rapidly growing nodule with a central keratin-filled crater, often considered a variant of SCC.

Lichen planus

Can cause flat-topped (planar) papules, but these are typically violaceous and polygonal.

Molluscum contagiousum

Smooth, dome-shaped papules with central umbilication, caused by a poxvirus, not HPV.

Poroma

A benign sweat gland tumor, often a solitary pink or red papule on the sole of the foot.

Punctate palmoplantar keratoderma

An inherited condition causing multiple, tiny, 'rain-drop' like keratoses on the palms and soles.

Punctate porokeratosis

Characterized by small keratotic papules, each surrounded by a distinct, thin, raised border known as a cornoid lamella.

Seborrhoiec keratosis

Has a greasy, warty, 'stuck-on' appearance and can be crumbly, unlike the firm texture of a wart.

Spitz naevus

A benign melanocytic nevus, typically a pink or red, smooth, dome-shaped papule in a child.

Squamous cell carcinoma

Can be verrucous but is distinguished by its firm, indurated base and potential for ulceration.

Trichilemmoma

A benign hair follicle tumor, often a smooth, skin-colored papule on the face, associated with Cowden syndrome if multiple.

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