A deep fungal infection causing chronic, warty, verrucous nodules and plaques, often on the lower extremities, with sclerotic bodies seen on histology.
Causes atrophic, scarred plaques with pigment changes, but does not cause the ulcerative or nodular gummas of tertiary syphilis.
A parasitic infection transmitted by sandflies, causing chronic ulcers or nodules, diagnosed by identifying amastigotes in a tissue sample.
Cutaneous tuberculosis presenting as 'apple-jelly' nodules on diascopy, which can lead to significant destruction but is caused by mycobacteria.
Can present in a tumor stage with large nodules, but these arise from pre-existing patches or plaques and biopsy shows a malignant T-cell infiltrate.
Can cause destructive nodules (lupus pernio), but these are typically violaceous, affect the nose, cheeks, and ears, and biopsy shows non-caseating granulomas.
