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Calcinosis

Presents as hard, white-to-yellow papules that may extrude chalky material, and feel much firmer than the soft papules of sebaceous hyperplasia.

Comedomes

The primary lesions of acne, which are plugs of keratin and sebum within follicles (blackheads/whiteheads), not lobulated papules.

Eruptive xanthomas

Sudden appearance of yellowish papules with an erythematous halo, typically on extensor surfaces, indicating severely elevated triglycerides.

Granuloma annulare

Presents as firm, skin-colored or erythematous papules that often form an annular (ring-like) configuration.

Milia

Small, firm, white, superficial keratin cysts without the central umbilication or yellowish hue of sebaceous hyperplasia.

Molluscum contagiousum

Flesh-colored or pearly, dome-shaped papules with central umbilication, caused by a poxvirus and common in children or the immunocompromised.

Neurofibroma

Soft, skin-colored, 'button-hole' papules that invaginate with pressure, often associated with neurofibromatosis.

Plane warts

Flat-topped, skin-colored or light brown papules caused by HPV, lacking the central umbilication and yellowish color of sebaceous hyperplasia.

Seborrhoiec keratoses

Have a 'stuck-on' appearance with a warty, greasy, or velvety surface, and are pigmented rather than yellowish.

Skin tags

Soft, pedunculated (on a stalk) papules commonly found in flexural areas like the neck and axillae.

Steatocystoma multiplex

Dermal cysts that contain oily fluid, appearing as yellowish or skin-colored papules and nodules, but without central umbilication.

Syringomas

Small, skin-colored or yellowish, firm papules, typically clustered on the lower eyelids, representing benign sweat duct tumors.

Xanthelasma

Yellowish plaques located on the eyelids, representing lipid deposits, which are flat or slightly raised, not umbilicated papules.

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