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Alezzandrini syndrome

This very rare syndrome is distinguished by unilateral facial vitiligo and poliosis, accompanied by ipsilateral hearing loss and vision changes.

Leprosy

The hypopigmented patches of leprosy are characterized by a loss of sensation, which is normal in the white patches of piebaldism.

Morphea

The hypopigmentation in morphea occurs within a plaque of hardened, sclerotic skin.

Pityriasis versicolor

This is a superficial fungal infection causing scaly, hypopigmented patches that are KOH positive.

Post inflammatory hypopigmentation

This is distinguished by a history of a preceding inflammatory skin condition in the affected area.

Vitiligo

Vitiligo is an acquired, progressive depigmentation, whereas piebaldism is a congenital, stable depigmentation, classically presenting with a white forelock and symmetrical patches on the trunk and extremities.

Vogt-Koyanagi-Harada syndrome

This is a systemic autoimmune disorder distinguished by vitiligo associated with severe uveitis, hearing loss, and meningitis.

Waardenburg syndrome

This is another congenital pigmentation disorder, distinguished from piebaldism by the presence of other key features, such as deafness and dystopia canthorum (widely spaced eyes).

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