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Hypertrophic lichen planus

This can also present as thickened, itchy plaques on the shins, but the scale is more prominent and the color is more violaceous than the brownish, rippled plaques of lichen amyloidosis.

Lichen simplex chronicus

This is a single, localized, leathery plaque resulting from chronic scratching, whereas lichen amyloidosis consists of multiple, discrete, "rippled" papules.

Papular mucinosis

Also known as scleromyxedema, this involves a widespread eruption of waxy papules associated with a monoclonal gammopathy, a different clinical picture and systemic association.

Pretibial myxedema

This is a specific finding in Graves' disease, presenting as indurated, non-pitting plaques with a "peau d'orange" (orange peel) texture on the shins.

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