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Carcinoma en cuirasse

This is a rare form of metastatic breast cancer causing diffuse, armor-like hardening of the chest wall skin, a much more extensive and infiltrative process than a discrete keloid.

Dermatofibroma

A DF is a small, firm dermal nodule that dimples with pressure, whereas a keloid is a raised, rubbery scar that grows beyond the original wound margins.

Dermatofibrosarcoma protruberans

DFSP is a low-grade malignancy that presents as a firm, indurated plaque, whereas a keloid is a benign fibrous growth with a smoother, more rubbery surface.

Goeminne syndrome

This is a rare genetic condition characterized by multiple keloids, torticollis, and renal dysplasia, a systemic syndrome not a simple isolated keloid.

Keloidal morphea

This is a rare variant of morphea (localized scleroderma) where sclerotic plaques are accompanied by keloid-like nodules.

Keloidal scleroderma

This refers to the development of keloid-like lesions within the hardened skin of systemic sclerosis.

Lobomycosis

This is a chronic deep fungal infection causing keloid-like nodules, diagnosed by finding the specific fungus on biopsy.

Nodular prurigo

These are intensely itchy, excoriated nodules, not the smooth, non-pruritic, fibrous growths of a keloid.

Rubenstein-Taybi syndrome

This is a genetic syndrome characterized by broad thumbs and toes, distinctive facial features, and a predisposition to forming keloids.

Type IV Ehlers-Danlos

This is a connective tissue disorder characterized by thin, translucent skin, easy bruising, and risk of arterial or organ rupture, where surgical scars may be atrophic, not keloidal.

Xanthoma disseminatum

This is a rare histiocytosis presenting with widespread yellowish-brown papules and nodules, a different pathology than the fibrous growth of a keloid.

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