An atypical nevus is distinguished by having some of the ABCDE features (asymmetry, border irregularity, etc.), whereas a simple junctional nevus is small, symmetric, and uniformly colored.
A CMN is present at birth, a key historical detail differentiating it from an acquired junctional nevus.
An intradermal nevus is a raised, dome-shaped papule, whereas a junctional nevus is completely flat (a macule).
A lentigo (solar or simple) and a junctional nevus can be clinically identical; biopsy is required for definitive differentiation, but lentigines do not typically evolve into other mole types.
This is melanoma in situ, distinguished by its larger size, irregular shape, color variegation, and slow, progressive growth on sun-damaged skin.
Melanoma is distinguished by significant and recent change in size, shape, or color, and having more pronounced ABCDE features.
This is distinguished from a benign junctional nevus by its larger size and clinical irregularity, confirmed by biopsy showing atypical melanocytes confined to the epidermis.
A blackhead is a keratin plug in a dilated follicle that can be expressed, unlike a junctional nevus which is a proliferation of melanocytes.
A pigmented BCC may appear as a dark macule but often has subtle features of a BCC, like a translucent or pearly quality.
A flat SK (macular SK or solar lentigo) can mimic a junctional nevus, but a more developed SK has a waxy, "stuck-on" texture.
