Simple intertrigo is inflammation in a skin fold, whereas the lesions of Langerhans cell histiocytosis (LCH) in this area are typically crusted, reddish-brown papules.
Diaper dermatitis is an irritant reaction, whereas LCH in this area is a neoplastic proliferation that is often erosive and purpuric.
JXG is a benign histiocytosis presenting as a solitary, reddish-yellow nodule, a different entity than LCH.
While LCH can mimic severe cradle cap, it is distinguished by its more purpuric, crusted, and erosive nature and its failure to respond to standard therapy.
This is a form of mastocytosis, where reddish-brown macules or papules form a wheal when stroked (Darier's sign), a pathognomonic feature not seen in histiocytosis.
