The chickenpox rash is more widespread, centripetal, and progresses through stages (macule to vesicle to crust), whereas HFMD is confined to its namesake locations with oval-shaped vesicles.
EM is characterized by classic target lesions, which are more complex than the simple vesicles or erosions of HFMD.
This is another coxsackievirus infection, but it is distinguished by being confined to the posterior oropharynx, without any lesions on the hands or feet.
Primary herpetic gingivostomatitis causes more severe oral disease with fiery red, swollen gums and is not typically associated with hand and foot lesions.
