Anal squamous cell carcinoma can present as a warty or ulcerative plaque, but it is distinguished by its induration, friability, and persistent nature.
These are histologically high-grade lesions (carcinoma in situ) that appear as multiple reddish-brown or violaceous papules, a different appearance than typical flesh-colored, verrucous warts.
These are the lesions of secondary syphilis, distinguished by their flat, moist, whitish-to-grey appearance, as opposed to the verrucous, papillomatous texture of genital warts (condylomata acuminata).
Molluscum are smooth, dome-shaped papules with a characteristic central umbilication, a very different morphology than a verrucous wart.
These are normal anatomic variants, presenting as multiple, uniform, small, dome-shaped papules arranged in rows around the corona of the glans penis.
Invasive vulvar cancer presents as a persistent, indurated, often ulcerated plaque or tumor, not as benign-appearing verrucous papules.
VIN can present as white, red, or pigmented patches or papules, and is distinguished from benign warts by its lack of response to simple therapy and on biopsy.
