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Calcinosis

Calcinosis cutis lesions are hard, whitish, and may extrude chalky material, unlike the softer, yellowish, lipid-filled papules of eruptive xanthomas.

Calcinosis cutis

This is a deposit of hard, stony calcium, which is much firmer than the soft, yellowish papules of eruptive xanthomas.

Disseminated granuloma annulare

Papular GA can appear as numerous skin-colored or reddish papules, but they lack the distinct yellow color of xanthomas.

Generalized eruptive histiocytomas

This is a benign proliferation of histiocytes presenting as crops of reddish-brown papules that are clinically and histologically distinct from lipid-laden xanthomas.

Gouty tophi

These are deposits of uric acid, often over joints, and lack the characteristic yellow hue of xanthomas.

Langerhan's cell histiocytosis

The cutaneous lesions of LCH are typically reddish-brown, scaly papules, often in a seborrheic distribution, and are composed of Langerhans cells, not foam cells.

Molluscum contagiousum

Molluscum are distinguished by their classic dome-shaped appearance with central umbilication.

Neurofibroma

These are soft, fleshy, skin-colored papules, not the yellowish papules seen in eruptive xanthomas.

Non-Langerhan's cell histiocytosis

This is a category of disorders; specific entities like juvenile xanthogranuloma present as a reddish-yellow nodule, but eruptive xanthomas are defined by their link to hypertriglyceridemia.

Papular xanthoma

These are normolipidemic, persistent, yellowish papules, distinguished from eruptive xanthomas by the normal lipid profile of the patient.

Plane warts

These are flat-topped, skin-colored papules, lacking the yellow color of xanthomas.

Rheumatoid nodule

These are firm, subcutaneous nodules over pressure points in a patient with rheumatoid arthritis.

Rosai-Dorfman disease

The cutaneous lesions are typically large, yellowish-brown nodules or plaques, often with massive lymphadenopathy, a different clinical picture.

Sebaceous gland hyperplasia

These are yellowish papules, but they are distinguished by their central umbilication and are typically found on the face of older adults.

Seborrhoeic keratoses

These benign growths have a waxy, "stuck-on" appearance, a different texture and color than xanthomas.

Steatocystoma multiplex

These are multiple cysts containing oily fluid, not solid papules filled with lipids.

Syringomas

These are small, benign sweat duct tumors, typically flat-topped and skin-colored, found around the eyes.

Xanthelasma

These are yellowish plaques specifically located on the eyelids, a specific location that defines the diagnosis.

Xanthoma disseminatum

This is a rare, normolipidemic histiocytosis characterized by a widespread eruption of red-to-yellow papules with a predilection for flexures and mucous membranes.

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