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Bartholin cyst

A Bartholin cyst is specifically located at the vaginal introitus, arising from the Bartholin gland, a distinct anatomical location.

Calcinosis cutis

This is a deposit of hard, rock-like calcium in the skin, which feels much firmer than the keratin-filled, cystic nature of an epidermoid cyst.

Dermatofibroma

This is a firm, solid dermal nodule that exhibits the "dimple sign" with lateral pressure, unlike a subcutaneous, dome-shaped cyst.

Dermoid cyst

A dermoid cyst is a congenital lesion, often found along embryonic fusion lines (like near the eyebrow), and contains dermal appendages like hair.

Gouty tophi

These are deposits of uric acid crystals, typically found over joints in individuals with a history of gout.

Keloid

A keloid is a firm, fibrous scar that grows beyond the borders of the original injury, a different pathology than an encapsulated cyst.

Lipoma

A lipoma is a soft, lobulated, benign tumor of fat cells that feels much less firm and discrete than an epidermoid cyst.

Lymph node

An enlarged lymph node is typically mobile and found along a lymphatic chain, and may be tender if reactive, unlike a skin-derived cyst.

Neurofibroma

This is a soft, fleshy papule or nodule that can often be "buttonholed" (invaginated) into the skin, a texture different from a firm cyst.

Rheumatoid nodule

This is a firm, non-tender nodule found over pressure points in patients with rheumatoid arthritis, and is associated with that underlying disease.

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