The rash of CMV is clinically indistinguishable from EBV; diagnosis relies on serology to differentiate the specific viral cause.
The rash of acute retroviral syndrome is often accompanied by prominent mucosal ulcers, a feature not typical for EBV mononucleosis.
Measles is distinguished by its prodrome of cough, coryza, and conjunctivitis, and the presence of Koplik spots inside the mouth.
The rubella rash is finer and spreads more rapidly, and is associated with prominent posterior auricular and suboccipital lymphadenopathy.
