A nodular BCC is typically pearly with surface telangiectasias and does not exhibit the characteristic "dimple sign" of a dermatofibroma.
DFSP is a much larger, firmer, plaque-like tumor that is fixed to underlying tissue, unlike the small, mobile, button-like nodule of a dermatofibroma.
This benign mole is typically softer, more dome-shaped, and lacks the firm, disc-like feel and positive dimple sign of a dermatofibroma.
A keloid is a firm, raised scar that extends beyond the boundaries of an original injury, a different history and morphology than a primary DF nodule.
An SK has a waxy, "stuck-on" appearance, unlike the smooth-surfaced, dermal nodule of a dermatofibroma.
A Spitz nevus is typically a pink or reddish, dome-shaped papule that grows rapidly, most often in a child, whereas a DF is a brownish, static papule in an adult.
A dermal wart can feel firm, but it has a verrucous surface, which is different from the smooth surface of a dermatofibroma.
