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Acrodermatitis verruciformis of Hopf

This presents as multiple, flat-topped, skin-colored papules resembling flat warts on the dorsum of the hands and feet, a different location and morphology than the greasy papules of Darier's.

Grover's disease

While histologically similar, Grover's disease is an acute, itchy eruption of papules on the trunk of older men that is transient, unlike the chronic, inherited nature of Darier's.

Hailey-Hailey disease

This blistering disease presents as erosions and maceration in the flexures, lacking the characteristic greasy, hyperkeratotic papules in the seborrheic areas seen in Darier's.

Intertrigo

Simple intertrigo is erythema and maceration in skin folds from friction and moisture, without the primary keratotic papules of Darier's disease.

Pemphigus vegetans

This is a variant of pemphigus presenting with vegetating, malodorous plaques in the flexures, a different morphology than the discrete papules of Darier's.

Psoriasis

Inverse psoriasis is characterized by smooth, non-scaly, red plaques in the flexures, unlike the crusted, keratotic papules of Darier's.

Pyoderma vegetans

This is a vegetating, pustular condition associated with inflammatory bowel disease, not the inherited keratotic papules of Darier's.

Seborrhoiec dermatitis

Seborrheic dermatitis presents with greasy scale and erythema, but it lacks the firm, "gritty" hyperkeratotic papules that are the hallmark of Darier's disease.

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