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Chron's disease

Cutaneous Crohn's can cause fistulas and "knife-cut" ulcers in the genital area, a different presentation than the discrete, cystic swelling of a Bartholin cyst.

Epidermoid cyst

While both are cysts, a Bartholin cyst is specifically located at the 4 or 8 o'clock position of the vaginal introitus, arising from the Bartholin gland itself.

Folliculitis

This is a superficial infection of multiple hair follicles, presenting as small pustules, unlike the deeper, singular, cystic nature of a Bartholin cyst.

Genital warts

These are verrucous (warty) papules caused by HPV, a completely different morphology from a smooth, subcutaneous cyst.

Hidradenitis suppuritiva

This chronic inflammatory condition involves recurrent, painful nodules, abscesses, and scarring in intertriginous areas, a more extensive and chronic process than a single Bartholin cyst.

Pilonidal sinus

A pilonidal sinus is located in the midline of the natal cleft (top of the buttocks), a distinct location from the vulva.

Syphilis

A primary syphilitic chancre is a painless ulcer, not a cyst, while secondary syphilis can cause condylomata lata, which are flat, moist, wart-like lesions.

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