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Contact dermatitis

This presents as an acute, often weeping or blistering inflammation of the lips due to a specific allergen, unlike the chronic, scaly, and indurated changes of actinic cheilitis.

Discoid lupus erythematosis

DLE of the lip is distinguished by atrophy and follicular plugging, and often occurs with characteristic DLE lesions elsewhere on the skin, unlike isolated actinic cheilitis.

Granulomatous cheilitis

Presents as persistent, non-tender, rubbery swelling and enlargement of the lip (macrocheilia), a diffuse swelling rather than the scaly, erosive surface of actinic cheilitis.

Lip licking

This is an irritant dermatitis confined to the perioral skin contacted by the tongue, sparing the vermilion border itself, which is the primary site of actinic cheilitis.

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